Two sample MR report
GBP3_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 24 | -0.0269549 | 0.0227944 | 0.2496207 |
| Weighted median | 24 | -0.0128944 | 0.0052376 | 0.0138215 |
| Inverse variance weighted | 24 | -0.0102877 | 0.0039472 | 0.0091509 |
| Simple mode | 24 | -0.0158393 | 0.0094085 | 0.1058025 |
| Weighted mode | 24 | -0.0149187 | 0.0083990 | 0.0889251 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.62494 | 22 | 0.7837079 |
| Inverse variance weighted | 17.17611 | 23 | 0.8005207 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.011241 | 0.0151412 | 0.4656914 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009313 | 0 | TRUE | 0.0036794 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
