Two sample MR report
GBP3_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | 0.0170669 | 0.0338282 | 0.6196983 |
| Weighted median | 21 | -0.0138074 | 0.0062236 | 0.0265171 |
| Inverse variance weighted | 21 | -0.0149434 | 0.0047485 | 0.0016497 |
| Simple mode | 21 | -0.0151013 | 0.0115234 | 0.2048802 |
| Weighted mode | 21 | -0.0145061 | 0.0101346 | 0.1677731 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 10.57311 | 19 | 0.9373650 |
| Inverse variance weighted | 11.48652 | 20 | 0.9326173 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.018738 | 0.019606 | 0.3512136 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009052 | 0 | TRUE | 0.0041936 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
