Two sample MR report
GLB1L_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.1260963 | 0.2441528 | 0.6569635 |
| Weighted median | 4 | -0.0565457 | 0.0316030 | 0.0735750 |
| Inverse variance weighted | 4 | -0.0585778 | 0.0273653 | 0.0323077 |
| Simple mode | 4 | -0.0463346 | 0.0412066 | 0.3426735 |
| Weighted mode | 4 | -0.0475391 | 0.0417014 | 0.3370650 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1952857 | 2 | 0.9069728 |
| Inverse variance weighted | 0.2727342 | 3 | 0.9650721 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0548667 | 0.1971524 | 0.8069181 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.14e-05 | 0 | TRUE | 0.5414433 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
