Two sample MR report
GRHPR_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0680857 | 0.2247576 | 0.8127434 |
| Weighted median | 3 | 0.0376433 | 0.0187175 | 0.0443110 |
| Inverse variance weighted | 3 | 0.0340978 | 0.0163851 | 0.0374322 |
| Simple mode | 3 | 0.0402210 | 0.0230479 | 0.2230839 |
| Weighted mode | 3 | 0.0402210 | 0.0224628 | 0.2152485 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0025150 | 1 | 0.9600034 |
| Inverse variance weighted | 0.2103152 | 2 | 0.9001826 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0453699 | 0.0995279 | 0.7277119 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.42e-05 | 0 | TRUE | 0.5786981 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
