Two sample MR report
HAGH_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0228346 | 0.2810465 | 0.9403612 |
| Weighted median | 5 | -0.0441142 | 0.0166715 | 0.0081429 |
| Inverse variance weighted | 5 | -0.0439147 | 0.0139726 | 0.0016728 |
| Simple mode | 5 | -0.0446134 | 0.0216295 | 0.1081311 |
| Weighted mode | 5 | -0.0445713 | 0.0221384 | 0.1143674 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0590800 | 3 | 0.9962477 |
| Inverse variance weighted | 0.0647198 | 4 | 0.9994876 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0083115 | 0.1106739 | 0.9448637 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.87e-05 | 0 | TRUE | 0.3729724 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
