Two sample MR report
HLA-A_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 37 | -0.0507819 | 0.0542407 | 0.3555693 |
| Weighted median | 37 | 0.0636929 | 0.0077766 | 0.0000000 |
| Inverse variance weighted | 37 | 0.0491574 | 0.0058891 | 0.0000000 |
| Simple mode | 37 | 0.0684469 | 0.0132252 | 0.0000088 |
| Weighted mode | 37 | 0.0680947 | 0.0136225 | 0.0000151 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 41.54025 | 35 | 0.2071520 |
| Inverse variance weighted | 45.61448 | 36 | 0.1308139 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0396539 | 0.0214025 | 0.0723625 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006671 | 1e-07 | TRUE | 0.0150707 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
