Two sample MR report
HLA-A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 51 | 0.2136199 | 0.1311159 | 0.1096742 |
| Weighted median | 51 | -0.1061472 | 0.0165878 | 0.0000000 |
| Inverse variance weighted | 51 | -0.0970068 | 0.0115756 | 0.0000000 |
| Simple mode | 51 | -0.1346432 | 0.0355003 | 0.0004027 |
| Weighted mode | 51 | -0.0668219 | 0.0365563 | 0.0735311 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 40.13818 | 49 | 0.8125113 |
| Inverse variance weighted | 45.79491 | 50 | 0.6427074 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1242433 | 0.0522385 | 0.0213315 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0009887 | 1e-07 | TRUE | 0.0029399 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
