Two sample MR report
HLA-C_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.0685706 | 0.0441260 | 0.1461566 |
| Weighted median | 14 | -0.0346190 | 0.0117220 | 0.0031436 |
| Inverse variance weighted | 14 | -0.0353999 | 0.0117591 | 0.0026089 |
| Simple mode | 14 | -0.0536871 | 0.0209779 | 0.0237741 |
| Weighted mode | 14 | -0.0313633 | 0.0166931 | 0.0828749 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 19.58708 | 12 | 0.0753114 |
| Inverse variance weighted | 29.14308 | 13 | 0.0062467 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0487296 | 0.0201395 | 0.0323409 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002582 | 0 | TRUE | 0.1300353 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
