Two sample MR report
HLA-C_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 40 | -0.0256480 | 0.0602995 | 0.6729861 |
| Weighted median | 40 | -0.0349978 | 0.0148595 | 0.0185105 |
| Inverse variance weighted | 40 | -0.0541697 | 0.0106469 | 0.0000004 |
| Simple mode | 40 | -0.0255360 | 0.0319585 | 0.4291088 |
| Weighted mode | 40 | -0.0293860 | 0.0312995 | 0.3535780 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 32.72065 | 38 | 0.7118027 |
| Inverse variance weighted | 32.95158 | 39 | 0.7412653 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0161499 | 0.0336069 | 0.6335902 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000692 | 0 | TRUE | 0.0127837 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
