Two sample MR report
HLA-DOA_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0815674 | 0.8346084 | 0.9379793 |
| Weighted median | 3 | 0.1272043 | 0.0711974 | 0.0739953 |
| Inverse variance weighted | 3 | 0.1293975 | 0.0551374 | 0.0189344 |
| Simple mode | 3 | 0.1243320 | 0.0793477 | 0.2576441 |
| Weighted mode | 3 | 0.1250009 | 0.0770548 | 0.2462175 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0337548 | 1 | 0.8542294 |
| Inverse variance weighted | 0.0370534 | 2 | 0.9816438 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.017878 | 0.3112797 | 0.9634766 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 1.86e-05 | 0 | TRUE | 0.6829261 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
