Two sample MR report
HLA-DPB1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0007490 | 0.0621961 | 0.9905502 |
| Weighted median | 17 | 0.0172871 | 0.0081258 | 0.0333842 |
| Inverse variance weighted | 17 | 0.0245415 | 0.0061018 | 0.0000577 |
| Simple mode | 17 | 0.0159358 | 0.0132308 | 0.2459328 |
| Weighted mode | 17 | 0.0154025 | 0.0124856 | 0.2351591 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.42374 | 15 | 0.6467133 |
| Inverse variance weighted | 12.57150 | 16 | 0.7037919 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0126548 | 0.0329216 | 0.7060815 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004529 | 0 | TRUE | 0.0439248 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
