Two sample MR report
HLA-DPB1_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | -0.0062685 | 0.0775407 | 0.9365707 |
| Weighted median | 18 | -0.0438402 | 0.0097289 | 0.0000066 |
| Inverse variance weighted | 18 | -0.0460342 | 0.0076675 | 0.0000000 |
| Simple mode | 18 | -0.0429843 | 0.0173144 | 0.0237800 |
| Weighted mode | 18 | -0.0421726 | 0.0165273 | 0.0206376 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.723047 | 16 | 0.9999118 |
| Inverse variance weighted | 2.988645 | 17 | 0.9999324 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0209954 | 0.0407392 | 0.6133468 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000528 | 0 | TRUE | 0.029369 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
