Two sample MR report
HLA-DQA1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 66 | -0.0338057 | 0.0290285 | 0.2485160 |
| Weighted median | 66 | 0.0541008 | 0.0047087 | 0.0000000 |
| Inverse variance weighted | 66 | 0.0507359 | 0.0054137 | 0.0000000 |
| Simple mode | 66 | 0.0774242 | 0.0121524 | 0.0000000 |
| Weighted mode | 66 | 0.0717594 | 0.0133353 | 0.0000011 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 237.7726 | 64 | 0 |
| Inverse variance weighted | 270.2950 | 65 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0564437 | 0.0190772 | 0.0043261 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008476 | 1.2e-06 | TRUE | 0.0075191 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
