Two sample MR report
HLA-DQA1_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 102 | 0.2505010 | 0.1278252 | 0.0528127 |
| Weighted median | 102 | -0.0463656 | 0.0109395 | 0.0000225 |
| Inverse variance weighted | 102 | -0.0383821 | 0.0150881 | 0.0109635 |
| Simple mode | 102 | -0.1679632 | 0.0134229 | 0.0000000 |
| Weighted mode | 102 | -0.1436272 | 0.0255182 | 0.0000002 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1930.466 | 100 | 0 |
| Inverse variance weighted | 2030.403 | 101 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1809735 | 0.0795398 | 0.0250245 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0013112 | 1.07e-05 | TRUE | 0.0016836 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
