Two sample MR report
HLA-DQA1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 35 | 0.0018233 | 0.0738146 | 0.9804418 |
| Weighted median | 35 | 0.0972449 | 0.0110790 | 0.0000000 |
| Inverse variance weighted | 35 | 0.0925128 | 0.0117138 | 0.0000000 |
| Simple mode | 35 | 0.1346392 | 0.0234389 | 0.0000019 |
| Weighted mode | 35 | 0.1138841 | 0.0277366 | 0.0002388 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 128.5649 | 33 | 0 |
| Inverse variance weighted | 134.5951 | 34 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0354349 | 0.0284818 | 0.222218 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004138 | 7e-07 | TRUE | 0.0631508 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
