Two sample MR report
HLA-DQA1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 48 | 0.0879141 | 0.1704222 | 0.6084224 |
| Weighted median | 48 | -0.1443131 | 0.0223956 | 0.0000000 |
| Inverse variance weighted | 48 | -0.1165115 | 0.0168848 | 0.0000000 |
| Simple mode | 48 | -0.1877582 | 0.0436669 | 0.0000856 |
| Weighted mode | 48 | -0.1638266 | 0.0421447 | 0.0003171 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 57.56223 | 46 | 0.1179475 |
| Inverse variance weighted | 59.38043 | 47 | 0.1062252 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0769789 | 0.0638617 | 0.2342137 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005996 | 1e-07 | TRUE | 0.0207425 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
