Two sample MR report
HLA-DQA2_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 122 | -0.0058010 | 0.0056231 | 0.3043178 |
| Weighted median | 122 | 0.0121123 | 0.0014783 | 0.0000000 |
| Inverse variance weighted | 122 | 0.0087864 | 0.0012347 | 0.0000000 |
| Simple mode | 122 | 0.0141824 | 0.0038628 | 0.0003601 |
| Weighted mode | 122 | 0.0136860 | 0.0034678 | 0.0001335 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 181.4470 | 120 | 0.0002498 |
| Inverse variance weighted | 192.1125 | 121 | 0.0000413 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0193124 | 0.0072716 | 0.0089853 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0033774 | 3e-07 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
