Two sample MR report
HLA-DQA2_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 208 | -0.0396849 | 0.0216316 | 0.0680102 |
| Weighted median | 208 | 0.0003873 | 0.0030875 | 0.9001804 |
| Inverse variance weighted | 208 | 0.0273980 | 0.0050263 | 0.0000001 |
| Simple mode | 208 | -0.0202227 | 0.0052802 | 0.0001699 |
| Weighted mode | 208 | -0.0150631 | 0.0033851 | 0.0000140 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4420.782 | 206 | 0 |
| Inverse variance weighted | 4638.420 | 207 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0840055 | 0.0263789 | 0.0016746 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0057533 | 3.74e-05 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
