Two sample MR report
HLA-DQA2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 102 | 0.0504045 | 0.0164619 | 0.0028253 |
| Weighted median | 102 | 0.0176484 | 0.0028128 | 0.0000000 |
| Inverse variance weighted | 102 | 0.0105008 | 0.0022783 | 0.0000040 |
| Simple mode | 102 | 0.0230265 | 0.0066572 | 0.0007957 |
| Weighted mode | 102 | 0.0223840 | 0.0066310 | 0.0010461 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 140.8558 | 100 | 0.0044664 |
| Inverse variance weighted | 149.2860 | 101 | 0.0012836 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.029142 | 0.011912 | 0.0161735 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0017615 | 1e-07 | TRUE | 7.25e-05 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
