Two sample MR report
HLA-DQA2_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 177 | -0.1759779 | 0.0587061 | 0.0031170 |
| Weighted median | 177 | 0.0115113 | 0.0061355 | 0.0606326 |
| Inverse variance weighted | 177 | 0.0500508 | 0.0089336 | 0.0000000 |
| Simple mode | 177 | 0.1726273 | 0.0114367 | 0.0000000 |
| Weighted mode | 177 | -0.0273673 | 0.0080604 | 0.0008473 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3388.976 | 175 | 0 |
| Inverse variance weighted | 3682.336 | 176 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1611263 | 0.0413982 | 0.0001411 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0033665 | 2.95e-05 | TRUE | 5e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
