Two sample MR report
HLA-DQA2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 160 | -0.0098673 | 0.0275722 | 0.7209182 |
| Weighted median | 160 | 0.0159829 | 0.0057133 | 0.0051502 |
| Inverse variance weighted | 160 | 0.0136559 | 0.0040890 | 0.0008387 |
| Simple mode | 160 | 0.0217126 | 0.0149497 | 0.1483676 |
| Weighted mode | 160 | 0.0211104 | 0.0134872 | 0.1195204 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 96.50134 | 158 | 0.9999698 |
| Inverse variance weighted | 97.24557 | 159 | 0.9999701 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0168035 | 0.0194781 | 0.389618 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0027335 | 0 | TRUE | 7e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
