Two sample MR report
HLA-DQB1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 26 | -0.0274200 | 0.0368654 | 0.4642250 |
| Weighted median | 26 | 0.0293512 | 0.0071903 | 0.0000446 |
| Inverse variance weighted | 26 | 0.0282576 | 0.0059006 | 0.0000017 |
| Simple mode | 26 | 0.0005598 | 0.0185075 | 0.9761096 |
| Weighted mode | 26 | 0.0016934 | 0.0158689 | 0.9158705 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 35.42521 | 24 | 0.0623400 |
| Inverse variance weighted | 38.87598 | 25 | 0.0379075 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0323445 | 0.021154 | 0.1393387 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004659 | 1e-07 | TRUE | 0.0426357 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
