Two sample MR report
HLA-DQB1_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 43 | -0.0919024 | 0.0575143 | 0.1177436 |
| Weighted median | 43 | -0.1649200 | 0.0112800 | 0.0000000 |
| Inverse variance weighted | 43 | -0.1691641 | 0.0101497 | 0.0000000 |
| Simple mode | 43 | -0.2075894 | 0.0259493 | 0.0000000 |
| Weighted mode | 43 | -0.1969589 | 0.0256369 | 0.0000000 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 137.4563 | 41 | 0 |
| Inverse variance weighted | 143.6968 | 42 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0437813 | 0.0320901 | 0.1799076 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006776 | 5.4e-06 | TRUE | 0.0238349 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
