Two sample MR report
HLA-DQB1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | 0.0896110 | 0.1301870 | 0.5005337 |
| Weighted median | 19 | -0.0578372 | 0.0218658 | 0.0081667 |
| Inverse variance weighted | 19 | -0.0417240 | 0.0177156 | 0.0185121 |
| Simple mode | 19 | -0.0613130 | 0.0385308 | 0.1289571 |
| Weighted mode | 19 | -0.0606713 | 0.0376785 | 0.1247431 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.551575 | 17 | 0.9957274 |
| Inverse variance weighted | 6.588490 | 18 | 0.9931619 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0639772 | 0.0628281 | 0.322814 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008543 | 0 | TRUE | 0.0054217 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
