Two sample MR report
HLA-DQB2_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.5700899 | 0.2477036 | 0.2609434 |
| Weighted median | 3 | 0.0719060 | 0.0248973 | 0.0038756 |
| Inverse variance weighted | 3 | 0.0907108 | 0.0200246 | 0.0000059 |
| Simple mode | 3 | 0.0666523 | 0.0292402 | 0.1502543 |
| Weighted mode | 3 | 0.0669258 | 0.0271257 | 0.1324180 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1509626 | 1 | 0.6976172 |
| Inverse variance weighted | 3.9088895 | 2 | 0.1416431 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.3763422 | 0.1941372 | 0.3031897 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 1.99e-05 | 1e-07 | TRUE | 0.6934505 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
