Two sample MR report
HLA-DQB2_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.3133041 | 0.5041350 | 0.5976873 |
| Weighted median | 4 | 0.0664370 | 0.0251760 | 0.0083175 |
| Inverse variance weighted | 4 | 0.0746259 | 0.0212607 | 0.0004480 |
| Simple mode | 4 | 0.0642085 | 0.0342783 | 0.1577603 |
| Weighted mode | 4 | 0.0640738 | 0.0342632 | 0.1582463 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4186892 | 2 | 0.8111157 |
| Inverse variance weighted | 0.6432351 | 3 | 0.8864672 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1936788 | 0.4087235 | 0.6822893 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.72e-05 | 0 | TRUE | 0.4761713 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
