Two sample MR report
HLA-DQB2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0523423 | 0.0531225 | 0.3533288 |
| Weighted median | 10 | -0.0358105 | 0.0133414 | 0.0072711 |
| Inverse variance weighted | 10 | -0.0308153 | 0.0142531 | 0.0306174 |
| Simple mode | 10 | -0.0662091 | 0.0243156 | 0.0234957 |
| Weighted mode | 10 | -0.0633419 | 0.0218946 | 0.0177961 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 23.26111 | 8 | 0.0030447 |
| Inverse variance weighted | 23.77966 | 9 | 0.0046636 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0152616 | 0.0361388 | 0.6839237 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001117 | 0 | TRUE | 0.3200845 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
