Two sample MR report
HLA-DQB2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.0856958 | 0.0637363 | 0.2017662 |
| Weighted median | 15 | 0.0560128 | 0.0208608 | 0.0072514 |
| Inverse variance weighted | 15 | 0.0441637 | 0.0156890 | 0.0048786 |
| Simple mode | 15 | 0.0579723 | 0.0324547 | 0.0957256 |
| Weighted mode | 15 | 0.0570790 | 0.0318692 | 0.0949244 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.071609 | 13 | 0.8984236 |
| Inverse variance weighted | 7.523611 | 14 | 0.9126412 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0326228 | 0.0485234 | 0.5131585 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001903 | 0 | TRUE | 0.1908347 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
