Two sample MR report
HLA-DRB5_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 100 | -0.0969021 | 0.0153229 | 0.0000000 |
| Weighted median | 100 | 0.0175594 | 0.0046708 | 0.0001703 |
| Inverse variance weighted | 100 | 0.0204086 | 0.0042069 | 0.0000012 |
| Simple mode | 100 | 0.0355124 | 0.0175354 | 0.0455408 |
| Weighted mode | 100 | -0.0170846 | 0.0132404 | 0.1999383 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 162.9951 | 98 | 4.14e-05 |
| Inverse variance weighted | 265.2656 | 99 | 0.00e+00 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0649314 | 0.0082805 | 0 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0017277 | 3e-07 | TRUE | 9.28e-05 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
