Two sample MR report
HLA-DRB5_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 180 | -0.2811720 | 0.0632949 | 0.0000156 |
| Weighted median | 180 | -0.0195910 | 0.0084773 | 0.0208330 |
| Inverse variance weighted | 180 | 0.1024008 | 0.0133774 | 0.0000000 |
| Simple mode | 180 | 0.2539488 | 0.0111200 | 0.0000000 |
| Weighted mode | 180 | -0.0455456 | 0.0065371 | 0.0000000 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3644.363 | 178 | 0 |
| Inverse variance weighted | 4425.147 | 179 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2016232 | 0.0326494 | 0 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0030328 | 4.35e-05 | TRUE | 3.7e-06 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
