Two sample MR report
HLA-DRB5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | -0.1734050 | 0.0912260 | 0.0797247 |
| Weighted median | 15 | 0.0315134 | 0.0168587 | 0.0615851 |
| Inverse variance weighted | 15 | 0.0349861 | 0.0165018 | 0.0339943 |
| Simple mode | 15 | 0.0599476 | 0.0313554 | 0.0765781 |
| Weighted mode | 15 | 0.0437437 | 0.0263585 | 0.1192266 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.77724 | 13 | 0.0182099 |
| Inverse variance weighted | 36.38913 | 14 | 0.0009122 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0786377 | 0.0339923 | 0.0377092 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001546 | 0 | TRUE | 0.2428319 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
