Two sample MR report
HLA-DRB5_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | 0.1126400 | 0.1672691 | 0.5092443 |
| Weighted median | 20 | 0.0956516 | 0.0268380 | 0.0003652 |
| Inverse variance weighted | 20 | 0.0854449 | 0.0212274 | 0.0000569 |
| Simple mode | 20 | 0.0978492 | 0.0505759 | 0.0680576 |
| Weighted mode | 20 | 0.0972407 | 0.0505517 | 0.0695205 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.537737 | 18 | 0.9977395 |
| Inverse variance weighted | 5.564603 | 19 | 0.9987739 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0100764 | 0.061476 | 0.8716301 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001965 | 0 | TRUE | 0.1835356 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
