Two sample MR report
HOMER2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 27 | 0.0459016 | 0.0249231 | 0.0774098 |
| Weighted median | 27 | 0.0215030 | 0.0047982 | 0.0000074 |
| Inverse variance weighted | 27 | 0.0192755 | 0.0041677 | 0.0000037 |
| Simple mode | 27 | 0.0324253 | 0.0096661 | 0.0024496 |
| Weighted mode | 27 | 0.0281807 | 0.0090248 | 0.0043619 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 41.84436 | 25 | 0.0186773 |
| Inverse variance weighted | 43.80926 | 26 | 0.0158457 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0232147 | 0.021426 | 0.2889336 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003533 | 1e-07 | TRUE | 0.0766482 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
