Two sample MR report
HOMER2_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | -0.0338408 | 0.0565101 | 0.5571725 |
| Weighted median | 19 | -0.0251515 | 0.0115217 | 0.0290377 |
| Inverse variance weighted | 19 | -0.0171889 | 0.0086696 | 0.0474049 |
| Simple mode | 19 | -0.0257518 | 0.0153645 | 0.1110091 |
| Weighted mode | 19 | -0.0272288 | 0.0122104 | 0.0387193 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.99945 | 17 | 0.5238737 |
| Inverse variance weighted | 16.08838 | 18 | 0.5863794 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0121874 | 0.0408698 | 0.769163 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002321 | 0 | TRUE | 0.1479893 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
