Two sample MR report
HOMER2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 26 | -0.1419812 | 0.0546287 | 0.0157393 |
| Weighted median | 26 | -0.0439455 | 0.0132112 | 0.0008798 |
| Inverse variance weighted | 26 | -0.0351786 | 0.0098714 | 0.0003657 |
| Simple mode | 26 | -0.0604332 | 0.0260520 | 0.0288140 |
| Weighted mode | 26 | -0.0578854 | 0.0241899 | 0.0245445 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 27.15583 | 24 | 0.2972421 |
| Inverse variance weighted | 31.61086 | 25 | 0.1695820 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0928668 | 0.0468016 | 0.0587744 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003254 | 0 | TRUE | 0.0879418 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
