Two sample MR report
HP_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.0135429 | 0.0569722 | 0.8169054 |
| Weighted median | 12 | 0.0115125 | 0.0065454 | 0.0786004 |
| Inverse variance weighted | 12 | 0.0111677 | 0.0051400 | 0.0298025 |
| Simple mode | 12 | 0.0031245 | 0.0131099 | 0.8160059 |
| Weighted mode | 12 | 0.0191631 | 0.0108574 | 0.1052763 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 13.55552 | 10 | 0.1942476 |
| Inverse variance weighted | 13.81279 | 11 | 0.2435261 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0209314 | 0.0480465 | 0.6723451 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006392 | 0 | TRUE | 0.0164899 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
