Two sample MR report
HP_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.2252621 | 0.1210328 | 0.0896382 |
| Weighted median | 13 | -0.0366953 | 0.0156736 | 0.0192211 |
| Inverse variance weighted | 13 | -0.0275773 | 0.0117834 | 0.0192655 |
| Simple mode | 13 | -0.0365087 | 0.0225762 | 0.1318179 |
| Weighted mode | 13 | -0.0395465 | 0.0203709 | 0.0760684 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.482989 | 11 | 0.8392756 |
| Inverse variance weighted | 9.176235 | 12 | 0.6878085 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1690294 | 0.1029969 | 0.129028 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005959 | 0 | TRUE | 0.0202835 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
