Two sample MR report
HSD17B12_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.1219115 | 0.3934603 | 0.7859834 |
| Weighted median | 4 | -0.0403382 | 0.0149792 | 0.0070823 |
| Inverse variance weighted | 4 | -0.0374490 | 0.0128229 | 0.0034949 |
| Simple mode | 4 | -0.0411896 | 0.0191913 | 0.1211347 |
| Weighted mode | 4 | -0.0411557 | 0.0193243 | 0.1230422 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0111496 | 2 | 0.9944407 |
| Inverse variance weighted | 0.1753675 | 3 | 0.9814643 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0818779 | 0.202049 | 0.7245392 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.26e-05 | 0 | TRUE | 0.4198047 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
