Two sample MR report
ICAM4_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0331940 | 0.1481046 | 0.8434729 |
| Weighted median | 4 | -0.0643132 | 0.0318933 | 0.0437462 |
| Inverse variance weighted | 4 | -0.0535048 | 0.0256059 | 0.0366585 |
| Simple mode | 4 | -0.0844249 | 0.0457469 | 0.1621520 |
| Weighted mode | 4 | -0.0834394 | 0.0462906 | 0.1692532 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.433806 | 2 | 0.2961460 |
| Inverse variance weighted | 2.866556 | 3 | 0.4126606 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.059909 | 0.1004619 | 0.6114578 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.05e-05 | 0 | TRUE | 0.5007154 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
