Two sample MR report
IDH2_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.1250783 | 0.1574582 | 0.4850228 |
| Weighted median | 5 | 0.0406606 | 0.0155670 | 0.0090020 |
| Inverse variance weighted | 5 | 0.0339191 | 0.0124785 | 0.0065638 |
| Simple mode | 5 | 0.0413395 | 0.0202981 | 0.1113711 |
| Weighted mode | 5 | 0.0413395 | 0.0207094 | 0.1166253 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1661623 | 3 | 0.9828576 |
| Inverse variance weighted | 1.1922520 | 4 | 0.8793726 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0706906 | 0.0697861 | 0.3856776 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001051 | 0 | TRUE | 0.3306093 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
