Two sample MR report
IRF5_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0611966 | 0.1235865 | 0.6380878 |
| Weighted median | 8 | 0.0350009 | 0.0132814 | 0.0084056 |
| Inverse variance weighted | 8 | 0.0360912 | 0.0109527 | 0.0009836 |
| Simple mode | 8 | 0.0298442 | 0.0208760 | 0.1959084 |
| Weighted mode | 8 | 0.0295897 | 0.0187879 | 0.1592728 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7143597 | 6 | 0.9941759 |
| Inverse variance weighted | 0.7559523 | 7 | 0.9978679 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0097606 | 0.0478594 | 0.8451397 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001103 | 0 | TRUE | 0.3192339 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
