Two sample MR report
JAML_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.0292801 | 0.1203319 | 0.8158569 |
| Weighted median | 8 | -0.0339719 | 0.0164114 | 0.0384514 |
| Inverse variance weighted | 8 | -0.0273497 | 0.0134133 | 0.0414505 |
| Simple mode | 8 | -0.0383452 | 0.0239517 | 0.1534248 |
| Weighted mode | 8 | -0.0385377 | 0.0245656 | 0.1606908 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.051195 | 6 | 0.9149305 |
| Inverse variance weighted | 2.051455 | 7 | 0.9569376 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0007691 | 0.0476453 | 0.9876438 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.00011 | 0 | TRUE | 0.3185879 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
