Two sample MR report
KANSL1-AS1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 62 | 0.0078017 | 0.0134660 | 0.5645129 |
| Weighted median | 62 | 0.0202049 | 0.0026586 | 0.0000000 |
| Inverse variance weighted | 62 | 0.0174134 | 0.0019737 | 0.0000000 |
| Simple mode | 62 | 0.0211395 | 0.0055572 | 0.0003320 |
| Weighted mode | 62 | 0.0208807 | 0.0054925 | 0.0003345 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 27.94949 | 60 | 0.9998683 |
| Inverse variance weighted | 28.47015 | 61 | 0.9998795 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.008996 | 0.0124673 | 0.4733615 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0018459 | 0 | TRUE | 4.45e-05 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
