Two sample MR report
KANSL1-AS1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 71 | 0.0187408 | 0.0092305 | 0.0461798 |
| Weighted median | 71 | 0.0182739 | 0.0023458 | 0.0000000 |
| Inverse variance weighted | 71 | 0.0157285 | 0.0017252 | 0.0000000 |
| Simple mode | 71 | 0.0187803 | 0.0049571 | 0.0003174 |
| Weighted mode | 71 | 0.0184561 | 0.0047677 | 0.0002407 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 29.49618 | 69 | 0.9999920 |
| Inverse variance weighted | 29.60654 | 70 | 0.9999945 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0030111 | 0.0090641 | 0.7407414 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0041163 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
