Two sample MR report
KANSL1-AS1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 86 | -0.0611206 | 0.0294575 | 0.0410587 |
| Weighted median | 86 | -0.0708272 | 0.0082187 | 0.0000000 |
| Inverse variance weighted | 86 | -0.0564672 | 0.0061098 | 0.0000000 |
| Simple mode | 86 | -0.0743925 | 0.0187349 | 0.0001494 |
| Weighted mode | 86 | -0.0739157 | 0.0176815 | 0.0000704 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 49.24249 | 84 | 0.9991112 |
| Inverse variance weighted | 49.26857 | 85 | 0.9993277 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0044646 | 0.0276482 | 0.8721031 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0053982 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
