Two sample MR report
KANSL1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0140151 | 0.1052893 | 0.8984586 |
| Weighted median | 8 | 0.0402438 | 0.0129071 | 0.0018210 |
| Inverse variance weighted | 8 | 0.0321546 | 0.0102276 | 0.0016671 |
| Simple mode | 8 | 0.0418870 | 0.0173570 | 0.0465507 |
| Weighted mode | 8 | 0.0415506 | 0.0186913 | 0.0616044 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.278925 | 6 | 0.6389871 |
| Inverse variance weighted | 4.308889 | 7 | 0.7435910 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0090908 | 0.0525173 | 0.8682633 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.81e-05 | 0 | TRUE | 0.5118301 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
