Two sample MR report
KDELR2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0372717 | 0.0679152 | 0.6029519 |
| Weighted median | 8 | 0.0305468 | 0.0157192 | 0.0519822 |
| Inverse variance weighted | 8 | 0.0265509 | 0.0135439 | 0.0499535 |
| Simple mode | 8 | 0.0310754 | 0.0240406 | 0.2371696 |
| Weighted mode | 8 | 0.0311883 | 0.0233995 | 0.2243227 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.8178579 | 6 | 0.9915863 |
| Inverse variance weighted | 0.8438080 | 7 | 0.9969708 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0052416 | 0.0325385 | 0.8773093 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.74e-05 | 0 | TRUE | 0.3739228 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
