Two sample MR report
KDELR2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0592788 | 0.1640297 | 0.7301923 |
| Weighted median | 8 | 0.0703801 | 0.0403122 | 0.0808322 |
| Inverse variance weighted | 8 | 0.0892892 | 0.0326374 | 0.0062230 |
| Simple mode | 8 | 0.0653827 | 0.0553558 | 0.2761192 |
| Weighted mode | 8 | 0.0659685 | 0.0582685 | 0.2948599 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.772305 | 6 | 0.8368342 |
| Inverse variance weighted | 2.807158 | 7 | 0.9022502 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0148666 | 0.0796326 | 0.8580561 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.38e-05 | 0 | TRUE | 0.3586747 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
