Two sample MR report
KLHDC9_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0432140 | 0.2241357 | 0.8594276 |
| Weighted median | 5 | -0.1516159 | 0.0247614 | 0.0000000 |
| Inverse variance weighted | 5 | -0.1525521 | 0.0161598 | 0.0000000 |
| Simple mode | 5 | -0.1512390 | 0.0319794 | 0.0091091 |
| Weighted mode | 5 | -0.1496351 | 0.0315065 | 0.0089752 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6788977 | 3 | 0.8781558 |
| Inverse variance weighted | 0.9181106 | 4 | 0.9219483 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0490877 | 0.1003646 | 0.658302 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.69e-05 | 2e-07 | TRUE | 0.4638962 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
