Two sample MR report
LGALS2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0575745 | 0.0556144 | 0.3308324 |
| Weighted median | 10 | 0.0242033 | 0.0076823 | 0.0016298 |
| Inverse variance weighted | 10 | 0.0239894 | 0.0061638 | 0.0000994 |
| Simple mode | 10 | 0.0267225 | 0.0111694 | 0.0403934 |
| Weighted mode | 10 | 0.0262669 | 0.0116290 | 0.0502806 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.10475 | 8 | 0.9974960 |
| Inverse variance weighted | 1.47397 | 9 | 0.9973353 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0212427 | 0.0349597 | 0.5602783 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000311 | 0 | TRUE | 0.0938714 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
